Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22513528 | 0.92 | KDM4E (0.34) | SLC9A1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL19738682 | 0.88 | KDM4E (0.37) | SLC9A1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL28718737 | 0.83 | — | — | |
| SCHEMBL19738627 | 0.81 | KDM4E (0.34) | SLC9A1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL19738601 | 0.76 | KDM4E (0.37) | SLC9A1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL3508542 | 0.73 | PPARG (0.39) | KDM4EHPGDALDH1A1GAAPOLB | |
| SCHEMBL23207680 | 0.71 | SLC9A1 (0.49) | SLC9A1ALDH1A1POLB | |
| SCHEMBL10233410 | 0.71 | HPGD (0.42) | SLC9A1KDM4EHPGDHTT | |
| SCHEMBL25508949 | 0.70 | LMNA (0.33) | SLC9A1KDM4EHPGDHTT | |
| SCHEMBL28610595 | 0.70 | ALDH1A1 (0.42) | KDM4EHPGDALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | YALE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20210145974-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | YALE UNIVERSITY | 2021-05-20 | — | — | US | disclosed |
| US-20210139436-A1 | Bi-functional Molecules to Degrade Circulating Proteins | YALE UNIVERSITY | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | MIF, ASGR1, FCGR2A | SLC9A1 4439/4885KDM4E 4546/4885HPGD 2922/4885 |
| US-20210145974-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR3B | SLC9A1 4541/4885KDM4E 4160/4885HPGD 4247/4885 |
| US-20210139436-A1 | Bi-functional Molecules to Degrade Circulating Proteins | MIF, ASGR1, FCGR2A | SLC9A1 4439/4885KDM4E 4546/4885HPGD 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.