Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23919168 | 0.83 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3SIGMAR1DRD2 | |
| SCHEMBL20463090 | 0.82 | HDAC6 (0.53) | SLC6A2SLC6A4SLC6A3SIGMAR1HDAC6 | |
| SCHEMBL26341182 | 0.81 | SIGMAR1 (0.45) | SLC6A2SLC6A4SLC6A3SIGMAR1HDAC6 | |
| SCHEMBL20234904 | 0.78 | HRH3 (0.46) | SLC6A2SLC6A4SLC6A3SIGMAR1HDAC6 | |
| SCHEMBL17972976 | 0.77 | DHFR (0.49) | SIGMAR1DRD2KDM4EDHFR | |
| SCHEMBL27363701 | 0.77 | HTR3A (0.45) | SIGMAR1HDAC6CYP1A2CYP2C9DHFR | |
| SCHEMBL27365699 | 0.77 | SIGMAR1 (0.53) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL17973027 | 0.75 | ALOX15 (0.45) | SIGMAR1DHFRHTR1A | |
| SCHEMBL19145298 | 0.75 | MEN1 (0.53) | SIGMAR1HDAC6DRD2KDM4ECYP1A2 | |
| SCHEMBL12156203 | 0.75 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139458-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS, INC. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139458-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | MDM2, CRBN, VHL | SLC6A2 4566/4885SLC6A4 4229/4885SLC6A3 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.