Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355189 | 0.90 | ITGB1 (0.43) | TYK2JAK2PSMB5ALDH1A1GPR55 | |
| SCHEMBL14500982 | 0.83 | PYGL (0.49) | PSMB5SLC6A3ITGB1ITGA4ITGA2 | |
| SCHEMBL5700509 | 0.81 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23355178 | 0.81 | ITGB2 (0.48) | PSMB5PPIAITGA4SMN1; SMN2ITGB2 | |
| SCHEMBL30695663 | 0.79 | GAA (0.54) | ALDH1A1GPR55KCNH2KDM4E | |
| SCHEMBL8804032 | 0.79 | ITGB2 (0.46) | TYK2JAK2PSMB5ALDH1A1ITGB1 | |
| SCHEMBL11056940 | 0.78 | ALDH1A1 (0.49) | TYK2JAK2PSMB5ALDH1A1ITGB1 | |
| SCHEMBL12020093 | 0.78 | MAPT (0.48) | ALDH1A1ITGB1ITGA4KDM4EMAPT | |
| SCHEMBL23355193 | 0.76 | ITGA4 (0.48) | ITGB1ITGA4SMN1; SMN2ITGB2ICAM1 | |
| SCHEMBL23355181 | 0.76 | NPC1 (0.40) | ALDH1A1SLC6A2CHRNA1CHRNGITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820864-A1 | METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS | Blade Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |