Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355170 | 0.90 | TYK2 (0.45) | ITGB1ITGA4ALDH1A1SMN1; SMN2GPR55 | |
| SCHEMBL5700509 | 0.76 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2MEN1NPC1KMT2A | |
| SCHEMBL23355178 | 0.76 | ITGB2 (0.48) | ITGA4SMN1; SMN2PSMB5MEN1NPC1 | |
| SCHEMBL14500982 | 0.75 | PYGL (0.49) | ITGB1ITGA4PSMB5SLC6A3PYGL | |
| SCHEMBL30695663 | 0.74 | GAA (0.54) | ALDH1A1GPR55KCNH2MEN1KMT2A | |
| SCHEMBL2845491 | 0.72 | F2R (0.63) | ITGB1ITGA4F2RSMN1; SMN2JAK2 | |
| SCHEMBL23355181 | 0.71 | NPC1 (0.40) | ITGB1ITGA4ALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL3914045 | 0.71 | LMNA (0.40) | ITGB1ITGA4F2RALDH1A1SMN1; SMN2 | |
| SCHEMBL11776569 | 0.71 | KMT2A (0.47) | ALDH1A1SMN1; SMN2GPR55SLC6A2CHRNA1 | |
| SCHEMBL1287117 | 0.70 | PGR (0.47) | ALDH1A1SMN1; SMN2HRH1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820864-A1 | METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS | Blade Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |