Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.48 |
| ▸ | ITGAL | P20701 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355193 | 0.88 | ITGA4 (0.48) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL8402593 | 0.83 | SMN1; SMN2 (0.59) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL8402596 | 0.83 | SMN1; SMN2 (0.59) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL23355181 | 0.82 | NPC1 (0.40) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL5700509 | 0.81 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL23355170 | 0.81 | TYK2 (0.45) | ITGB2ICAM1ITGALSMN1; SMN2PSMB5 | |
| SCHEMBL7135256 | 0.78 | ITGB2 (0.53) | ITGB2ICAM1ITGALRAB9AMEN1 | |
| SCHEMBL318250 | 0.77 | ITGB2 (0.40) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL16857265 | 0.77 | CES2 (0.49) | ITGB2ICAM1ITGALLMNASMN1; SMN2 | |
| SCHEMBL1287117 | 0.76 | PGR (0.47) | LMNASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820864-A1 | METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS | Blade Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |