Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004661 | 0.72 | HPGDS (0.53) | HPGDSMAPK14TP53CDK8BRD4 | |
| SCHEMBL8001356 | 0.65 | HPGDS (0.70) | HPGDSHDAC3HDAC1HDAC2 | |
| SCHEMBL2960085 | 0.64 | ALDH1A1 (0.57) | HPGDSALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12670576 | 0.64 | HPGDS (0.48) | HPGDSTP53CDK8BRD4HDAC3 | |
| SCHEMBL17077544 | 0.63 | HPGDS (0.46) | HPGDSHPGDCDK8BRD4DGAT2 | |
| SCHEMBL9979308 | 0.62 | SMN1; SMN2 (0.48) | HPGDSALDH1A1HPGDBRD4SMN1; SMN2 | |
| SCHEMBL21604631 | 0.62 | HPGD (0.35) | HPGDSALDH1A1HPGDMAP4K4 | |
| SCHEMBL12670572 | 0.62 | HPGDS (0.46) | HPGDSTP53CSNK1DCDK8HDAC3 | |
| SCHEMBL13614180 | 0.61 | MEN1 (0.66) | TP53ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL18897476 | 0.60 | HPGDS (0.41) | HPGDSALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008340-B2 | Modulators of ROR-gamma | VITAE PHARMACEUTICALS, LLC (US) | 2021-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008340-B2 | Modulators of ROR-gamma | RORC, RORB, RORA | HPGDS 380/4885MAPK14 1883/4885TP53 4309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.