Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.32 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644170 | 0.98 | ACHE (0.38) | ACHEAPEX1NPSR1BBOX1CHRM5 | |
| Hydrochloric Acid SCHEMBL3409063 | 0.96 | ACHE (0.36) | ACHEAPEX1NPSR1BBOX1CHRM5 | |
| SCHEMBL4685734 | 0.86 | CHRM2 (0.35) | ACHECHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL16776767 | 0.82 | ZDHHC20 (0.42) | ZDHHC20ZDHHC2LMNATSHR | |
| SCHEMBL14341773 | 0.82 | ZDHHC20 (0.38) | ZDHHC20ZDHHC2LMNATSHR | |
| Hydrochloric Acid SCHEMBL7803046 | 0.81 | ACHE (0.36) | ACHEAPEX1NPSR1BBOX1CHRM5 | |
| SCHEMBL23903201 | 0.81 | ACHE (0.39) | ACHEAPEX1NPSR1BBOX1CHRM5 | |
| Hydrochloric Acid SCHEMBL20987234 | 0.80 | HTT (0.46) | ZDHHC20ZDHHC2KMT2ADNM1 | |
| Hydrochloric Acid SCHEMBL20987232 | 0.80 | HTT (0.46) | ZDHHC20ZDHHC2KMT2ADNM1 | |
| Hydrochloric Acid SCHEMBL20987235 | 0.80 | HTT (0.46) | ZDHHC20ZDHHC2KMT2ADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230302205-A1 | NANOFIBER REINFORCEMENT OF ATTACHED HYDROGELS | UNIV DUKE (US) | 2023-09-28 | — | — | US | claimed |
| US-11707555-B2 | Nanofiber reinforcement of attached hydrogels | DUKE UNIVERSITY (US) | 2023-07-25 | — | — | US | claimed |
| EP-4175689-A1 | NANOFIBER REINFORCEMENT OF ATTACHED HYDROGELS | Duke University (US) | 2023-05-10 | — | — | EP | claimed |
| EP-2823283-A2 | SORPTION OF WATER FROM A SAMPLE USING A POLYMERIC DRYING AGENT | Dionex Corporation (US) | 2015-01-14 | — | — | EP | claimed |
| US-20130233093-A1 | SORPTION OF WATER FROM A SAMPLE USING A POLYMERIC DRYING AGENT | DIONEX CORPORATION | 2013-09-12 | — | — | US | claimed |
| WO-2013134098-A2 | SORPTION OF WATER FROM A SAMPLE USING A POLYMERIC DRYING AGENT | DIONEX CORPORATION (US) | 2013-09-12 | — | — | WO | claimed |
| US-20050048554-A1 | Method of making and using hybrid polymeric thin films for bio-microarray applications | ENGERY, UNITED STATES DEPARTMENT OF | 2005-03-03 | — | — | US | claimed |
| US-5200448-A | With maleic anhydride-based polymeric surfactant | EXXON CHEMICAL PATENTS INC. (US) | 1993-04-06 | — | — | US | claimed |
| US-4568731-A | ADDING 1,3-DIONE MOIETIES TO ENHANCE PERFORMANCE CHARACTERISTICS AND RATES OF POLYMERIZATION | AMERICAN CYANAMID COMPANY (US) | 1986-02-04 | — | — | US | claimed |
| EP-0049766-B1 | HIGH CONCENTRATION WATER SOLUBLE POLYMERS AS WATER-IN-OIL EMULSIONS | AMERICAN CYANAMID COMPANY (US) | 1985-03-27 | — | — | EP | claimed |
| US-4339371-A | High concentration water-soluble polymers in water-in-oil emulsions | AMERICAN CYANAMID COMPANY (US) | 1982-07-13 | — | — | US | claimed |
| EP-0049766-A1 | High concentration water soluble polymers as water-in-oil emulsions | AMERICAN CYANAMID COMPANY (US) | 1982-04-21 | — | — | EP | claimed |
| US-20260083565-A1 | DRY HYDROGEL IMPLANTS | SPARTA BIOMEDICAL INC (US) | 2026-03-26 | — | — | US | disclosed |
| US-12497556-B2 | Emulsions including polymers, treatment fluids including emulsions, and methods for treating subterranean formations | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-12-16 | — | — | US | disclosed |
| EP-4590354-A2 | DRY HYDROGEL IMPLANTS | Sparta Biomedical Inc. (US) | 2025-07-30 | — | — | EP | disclosed |
| EP-4518921-A2 | SYNTHETIC HYDROGEL COMPOSITE | Duke University (US) | 2025-03-12 | — | — | EP | disclosed |
| US-4622356-A | IMPROVED PROCESS AND PROPERTIES DUE TO PRESENCE OF DIKETONE COMPOUND | AMERICAN CYANAMID COMPANY (US) | 1986-11-11 | — | — | US | disclosed |
| US-4568731-A | ADDING 1,3-DIONE MOIETIES TO ENHANCE PERFORMANCE CHARACTERISTICS AND RATES OF POLYMERIZATION | AMERICAN CYANAMID COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0049766-B1 | HIGH CONCENTRATION WATER SOLUBLE POLYMERS AS WATER-IN-OIL EMULSIONS | AMERICAN CYANAMID COMPANY (US) | 1985-03-27 | — | — | EP | disclosed |
| US-4339371-A | High concentration water-soluble polymers in water-in-oil emulsions | AMERICAN CYANAMID COMPANY (US) | 1982-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260083565-A1 | DRY HYDROGEL IMPLANTS | CD44, COL2A1, COL1A1 | ACHE 1460/4885CHRM1 1314/4885CHRM3 1403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.