Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | SPOP | O43791 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1132035 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL8745854 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL1132191 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL1132036 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL1132192 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL1132808 | 0.90 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL1131847 | 0.87 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL12374918 | 0.87 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL7770365 | 0.87 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT | |
| SCHEMBL5592457 | 0.87 | TDP1 (0.55) | TDP1KDM4EHSD17B10TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071761-B2 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-06 | — | — | US | disclosed |
| EP-1405922-B1 | Substrates for beta-lactamase and uses thereof | UNIV CALIFORNIA (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-09 | — | — | US | disclosed |
| US-7157575-B2 | Substrates for β-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-01-02 | — | — | US | disclosed |
| EP-1405922-A2 | Substrates for beta-lactamase and uses thereof | The Regents of the University of California (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-0982398-B1 | Nucleic acids and uses thereof for the assay of beta-lactamase | UNIV CALIFORNIA (US) | 2003-11-05 | — | — | EP | disclosed |
| US-20030119085-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-26 | — | — | US | disclosed |
| US-6472205-B1 | EXPRESSION CONTROL SEQUENCES ADAPTED FOR FUNCTION IN EUKARYOTIC CELL, OPERABLY LINKED TO SEQUENCE CODING CYTOSOLIC BETA-LACTAMASE; SCREENING BY CONTACTING HOST CELL WITH MEMBRANE PERMEABLE, FLUORESCENT SUBSTRATE OF BETA-LACTAMASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-10-29 | — | — | US | disclosed |
| US-6291162-B1 | DETERMINING AMOUNT OF LACTAMASE ACTIVITY; TRANSFECTING CELLS WITH A NUCLEIC ACID HAVING AN EXPRESSION CONTROL SEQUENCE LINKED TO A SECRETION DEFECTIVE SEQUENCE; MIXING CELLS WITH LACTAMASE SUBSTRATE; DETERMINE AMOUNT OF CLEAVED SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-09-18 | — | — | US | disclosed |
| EP-0817785-B1 | SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF | UNIV CALIFORNIA (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-0982398-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-03-01 | — | — | EP | disclosed |
| US-5955604-A | Substrates for β-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-21 | — | — | US | disclosed |
| US-5741657-A | MEASURING GENE EXPRESSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1996030540-A2 | SUBSTRATES FOR BETA-LACTAMASE AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-10-03 | — | — | WO | disclosed |
| EP-0047560-B1 | PROCESS FOR THE PREPARATION OF 7-ACYLAMINO-3-(THIO-SUBSTITUTED)METHYL-3-CEPHEM-4-CARBOXYLIC ACID 1-OXIDE DERIVATIVES | GIST-BROCADES N.V. (NL) | 1985-04-10 | — | — | EP | disclosed |
| US-4472574-A | Process for the manufacture of a cephem carboxylic acid derivative | HOFFMAN-LA ROCHE INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4379923-A | Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem-4-carboxylic acid-1-oxide derivatives | GIST-BROCADES N.V. (NL) | 1983-04-12 | — | — | US | disclosed |
| EP-0047560-A2 | Process for the preparation of 7-acylamino-3-(thio-substituted)methyl-3-cephem-4-carboxylic acid 1-oxide derivatives | GIST-BROCADES N.V. (NL) | 1982-03-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119085-A1 | Substrates for beta-lactamase and uses thereof | CMBL, GLB1, BBOX1 | TDP1 2070/4885KDM4E 1286/4885HSD17B10 172/4885 |
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | CMBL, DBH, NCEH1 | TDP1 3459/4885KDM4E 886/4885HSD17B10 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.