Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11158144 | 0.84 | TDP1 (0.36) | ALDH1A1MEN1KMT2AGAAGFER | |
| SCHEMBL8763608 | 0.84 | TSHR (0.42) | ALDH1A1CYP3A4TSHRHIF1A | |
| SCHEMBL953145 | 0.83 | CES2 (0.40) | ALDH1A1MEN1KMT2AGAAGFER | |
| SCHEMBL10079518 | 0.80 | CYP3A4 (0.38) | ALDH1A1MEN1KMT2AGAACYP3A4 | |
| SCHEMBL7956277 | 0.79 | IDO1 (0.38) | ALDH1A1MEN1KMT2AGAAGFER | |
| SCHEMBL1874935 | 0.78 | GABRA1 (0.58) | ALDH1A1MEN1KMT2AGAATDP1 | |
| SCHEMBL6141021 | 0.78 | CYP3A4 (0.40) | ALDH1A1MEN1KMT2AGAACYP3A4 | |
| SCHEMBL11566406 | 0.76 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2AGAAGFER | |
| SCHEMBL11158774 | 0.76 | FFAR1 (0.48) | CYP11B1CYP11B2 | |
| SCHEMBL4910575 | 0.76 | IDO1 (0.37) | ALDH1A1MEN1KMT2AGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663960-B1 | AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE SPA (IT) | 2011-08-24 | — | — | EP | disclosed |
| US-7674806-B2 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2010-03-09 | — | — | US | disclosed |
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA.R.MA S.P.A (IT) | 2007-07-05 | — | — | US | disclosed |
| CN-1882530-A | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG (IT) | 2006-12-20 | — | — | CN | disclosed |
| EP-1663960-A2 | AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028425-A2 | AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ PHA.R.MA S.P.A. (IT) | 2005-03-31 | — | — | WO | disclosed |
| CN-1107068-C | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydro-pyrrolo (3,2-D] pyrimidine-4-ones | NOVARTIS AG (CH) | 2003-04-30 | — | — | CN | disclosed |
| CN-1257503-A | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydro-pyrrolo (3,2-D] pyrimidine-4-ones | NOVARTIS AG (CH) | 2000-06-21 | — | — | CN | disclosed |
| EP-0135249-B1 | STYRENE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1986-11-12 | — | — | EP | disclosed |
| US-4557871-A | Novel styrene derivatives of the general formula | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1985-12-10 | — | — | US | disclosed |
| EP-0135249-A1 | Styrene derivatives | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1985-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | MMP8, CXCL8, MPO | ALDH1A1 1638/4885MEN1 1994/4885KMT2A 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.