Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14894969 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MCL1HTTCDK2 | |
| SCHEMBL22345876 | 0.77 | CA1 (0.39) | ALDH1A1SMN1; SMN2ESR1HTTCDK2 | |
| SCHEMBL4066986 | 0.76 | GAA (0.54) | OPRM1OPRK1ALDH1A1SMN1; SMN2HTT | |
| Phenolsulphonic Acid SCHEMBL3326508 | 0.75 | MYC (0.44) | ALDH1A1SMN1; SMN2MCL1HTTCDK2 | |
| SCHEMBL13588847 | 0.75 | GABRA1 (0.41) | ALDH1A1SMN1; SMN2GABRA1GABRB2ESR1 | |
| SCHEMBL27729470 | 0.74 | KMT2A (0.51) | ALDH1A1SMN1; SMN2HTTSERPINE1HPGD | |
| SCHEMBL1902646 | 0.74 | IRAK4 (0.45) | OPRM1OPRK1ALDH1A1MCL1ADAMTS4 | |
| SCHEMBL30047795 | 0.73 | HTR6 (0.53) | ALDH1A1HTTHTR6 | |
| SCHEMBL23409893 | 0.73 | HTR6 (0.53) | ALDH1A1HTTHTR6 | |
| SCHEMBL6904423 | 0.73 | OPRM1 (0.58) | OPRM1OPRK1ALDH1A1SMN1; SMN2ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022249006-A1 | USE OF 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |
| US-20220340573-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-10-27 | — | — | US | disclosed |
| EP-4065228-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | Novartis AG (CH) | 2022-10-05 | — | — | EP | disclosed |
| US-11427586-B2 | 1,2,4-oxadiazole derivatives as liver X receptor agonists | NOVARTIS AG (CH) | 2022-08-30 | — | — | US | disclosed |
| CN-114746149-A | 1,2, 4-oxadiazole derivatives as liver X receptor agonists | 诺华股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| US-20220064164-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-03-03 | — | — | US | disclosed |
| WO-2021105857-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064164-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NR1H4, GPBAR1, NR1I2 | OPRM1 166/4885OPRK1 185/4885HSP90AA1 2371/4885 |
| US-11427586-B2 | 1,2,4-oxadiazole derivatives as liver X receptor agonists | NR1H4, GPBAR1, NR1I2 | OPRM1 166/4885OPRK1 185/4885HSP90AA1 2371/4885 |
| US-20220340573-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NR1H4, GPBAR1, NR1I2 | OPRM1 166/4885OPRK1 185/4885HSP90AA1 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.