Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414960 | 0.84 | ALDH1A1 (0.38) | ALDH1A1LMNAALOX15NR1I2CYP2C9 | |
| SCHEMBL8405048 | 0.80 | LMNA (0.38) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL8403336 | 0.79 | ALDH1A1 (0.37) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL7996227 | 0.77 | ALDH1A1 (0.38) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL7996188 | 0.77 | ALDH1A1 (0.38) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL728580 | 0.77 | ALDH1A1 (0.38) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL29459356 | 0.77 | ALDH1A1 (0.38) | ALDH1A1LMNACYP3A4OPRM1OPRD1 | |
| SCHEMBL8000482 | 0.76 | LMNA (0.38) | ALDH1A1LMNAHTTCYP3A4OPRD1 | |
| SCHEMBL7127931 | 0.76 | ESR1 (0.37) | ALDH1A1LMNAALOX15NR1I2CYP2C9 | |
| SCHEMBL9721391 | 0.75 | OPRM1 (0.41) | ALDH1A1LMNAALOX15CYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2022-12-20 | — | — | US | disclosed |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ORMDL3, TALDO1, TAC3 | ALDH1A1 199/4885LMNA 3719/4885ALOX15 2266/4885 |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ORMDL3, TALDO1, TAC3 | ALDH1A1 202/4885LMNA 3735/4885ALOX15 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.