Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21792151 | 0.85 | RARB (0.48) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL17446870 | 0.76 | NOTUM (0.57) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL31396115 | 0.74 | NPY5R (0.47) | KDM4EHSD17B10SMN1; SMN2POLBNOTUM | |
| SCHEMBL24704618 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL26722272 | 0.73 | RARA (0.78) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL21792031 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL2502232 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL30183723 | 0.71 | CASP3 (0.45) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL17436145 | 0.71 | NOTUM (0.59) | KDM4EALDH1A1HSD17B10ALOX15CASP1 | |
| SCHEMBL3931904 | 0.71 | CASP3 (0.54) | ALDH1A1CASP3SMN1; SMN2CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | KDM4E 3907/4885ALDH1A1 1260/4885HSD17B10 638/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | KDM4E 4149/4885ALDH1A1 658/4885HSD17B10 785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.