Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195832 | 0.86 | L3MBTL1 (0.49) | TLR8TLR7L3MBTL1 | |
| SCHEMBL23472288 | 0.85 | TLR8 (0.38) | TLR8TLR7KDM4ECYP3A4L3MBTL1 | |
| SCHEMBL20219396 | 0.85 | TLR8 (0.35) | TLR8TLR7KDM4EALDH1A1CYP3A4 | |
| SCHEMBL23472526 | 0.82 | TLR8 (0.47) | TLR8TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL23472623 | 0.81 | LMNA (0.42) | TLR8TLR7ALDH1A1GAAL3MBTL1 | |
| SCHEMBL20219723 | 0.80 | ALDH1A1 (0.38) | TLR8TLR7ALDH1A1FLT3TYRO3 | |
| SCHEMBL20219572 | 0.80 | CYP2D6 (0.43) | TLR8TLR7KDM4EALDH1A1NPC1 | |
| SCHEMBL20219391 | 0.80 | TLR8 (0.35) | TLR8TLR7KDM4EALDH1A1CYP3A4 | |
| SCHEMBL20219386 | 0.79 | SCN9A (0.36) | TLR8TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL20219304 | 0.79 | TLR8 (0.36) | TLR8TLR7CYP3A4L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |