Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 9/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 9/20 | 0.35 |
| ▸ | MERTK | Q12866 | 9/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 9/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ITK | Q08881 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472521 | 0.92 | FLT3 (0.34) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL15469977 | 0.81 | L3MBTL1 (0.50) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219350 | 0.81 | ALDH1A1 (0.32) | TLR8TLR7ALDH1A1POLB | |
| SCHEMBL20219474 | 0.78 | TLR8 (0.33) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL23472434 | 0.76 | CYP2D6 (0.40) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL20219702 | 0.76 | ALDH1A1 (0.35) | TLR8TLR7L3MBTL1ALDH1A1POLB | |
| SCHEMBL23472593 | 0.76 | CYP1A2 (0.43) | TLR8TLR7TYRO3MERTKGAS6 | |
| SCHEMBL20219444 | 0.75 | TLR7 (0.42) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL20219428 | 0.75 | TLR7 (0.40) | TLR8TLR7FLT3TYRO3MERTK | |
| SCHEMBL20219512 | 0.74 | TLR8 (0.38) | TLR8TLR7FLT3TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |