Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | LATS1 | O95835 | 2/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472434 | 0.88 | CYP2D6 (0.40) | TLR7TLR8LATS1LATS2CYP1A2 | |
| SCHEMBL23472518 | 0.84 | TLR7 (0.45) | TLR7TLR8CNR2LATS1LATS2 | |
| SCHEMBL23472423 | 0.83 | MEN1 (0.45) | LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL15470120 | 0.83 | TLR7 (0.55) | TLR7TLR8CYP1A2CYP3A4 | |
| SCHEMBL23472511 | 0.81 | CHRNB2 (0.43) | TLR7TLR8CYP1A2CYP3A4HTT | |
| SCHEMBL20219267 | 0.79 | TLR7 (0.44) | TLR7TLR8CNR2LATS1LATS2 | |
| SCHEMBL23472437 | 0.79 | KMT2A (0.37) | TLR7TLR8STK17ACYP1A2CYP3A4 | |
| SCHEMBL20219406 | 0.78 | S1PR4 (0.35) | TLR7TLR8STK17ALMNAHTT | |
| SCHEMBL23472425 | 0.77 | CASP6 (0.41) | TLR7TLR8CYP1A2CYP3A4LMNA | |
| SCHEMBL23472593 | 0.77 | CYP1A2 (0.43) | TLR7TLR8STK17ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |