Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472550 | 0.88 | LMNA (0.41) | LMNAALDH1A1PDE3BPDE3AP2RY12 | |
| SCHEMBL15470213 | 0.88 | L3MBTL1 (0.46) | LMNATLR7TLR8L3MBTL1 | |
| SCHEMBL23472109 | 0.81 | TLR8 (0.38) | LMNAALDH1A1HTTGAATLR7 | |
| SCHEMBL23472288 | 0.79 | TLR8 (0.38) | LMNATLR7TLR8L3MBTL1 | |
| SCHEMBL20219396 | 0.77 | TLR8 (0.35) | ALDH1A1POLBBRD4TLR7TLR8 | |
| SCHEMBL13195063 | 0.76 | L3MBTL1 (0.50) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219709 | 0.75 | L3MBTL1 (0.44) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219707 | 0.75 | L3MBTL1 (0.44) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219391 | 0.74 | TLR8 (0.35) | ALDH1A1POLBTLR7TLR8L3MBTL1 | |
| SCHEMBL23472526 | 0.74 | TLR8 (0.47) | LMNAALDH1A1PDE3AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |