Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219563 | 0.86 | TLR8 (0.36) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL15470366 | 0.86 | L3MBTL1 (0.49) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219475 | 0.86 | L3MBTL1 (0.49) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219474 | 0.83 | TLR8 (0.33) | TLR8TLR7ALDH1A1POLBL3MBTL1 | |
| SCHEMBL20219396 | 0.80 | TLR8 (0.35) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL23472288 | 0.80 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1CRHR1 | |
| SCHEMBL23472109 | 0.80 | TLR8 (0.38) | TLR8TLR7CYP3A4ALDH1A1L3MBTL1 | |
| SCHEMBL23472526 | 0.77 | TLR8 (0.47) | TLR8TLR7CYP3A4ALDH1A1POLB | |
| SCHEMBL20219723 | 0.75 | ALDH1A1 (0.38) | TLR8TLR7ALDH1A1POLBCRHR1 | |
| SCHEMBL20219512 | 0.74 | TLR8 (0.38) | TLR8TLR7CYP3A4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |