Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23487709 | 0.89 | ASIC3 (0.50) | PIK3CAASIC3TGFBR1SMOPIM1 | |
| SCHEMBL25105698 | 0.86 | PIK3CA (0.45) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL21207992 | 0.86 | PIK3CA (0.45) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL17229036 | 0.85 | PIK3CA (0.47) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL17229046 | 0.85 | PIK3CA (0.47) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL23487540 | 0.84 | PIM1 (0.40) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL23487645 | 0.84 | ALDH1A1 (0.42) | PIK3CAASIC3TGFBR1PRKDCSMO | |
| SCHEMBL17115687 | 0.84 | ASIC3 (0.41) | PIK3CAASIC3TGFBR1SMOPIM1 | |
| SCHEMBL21662273 | 0.83 | TGFBR1 (0.52) | PIK3CAASIC3TGFBR1SMOMAPT | |
| SCHEMBL23956266 | 0.83 | TGFBR1 (0.52) | PIK3CAASIC3TGFBR1SMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230056324-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2023-02-23 | — | — | US | disclosed |
| WO-2021110720-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2021-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230056324-A1 | METAL COMPLEXES | MCU, IMMT, SOD1 | PIK3CA 4505/4885ASIC3 937/4885TGFBR1 3596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.