SCHEMBL2349847

SCHEMBL2349847

O=C(O)c1ccc(-c2ccccc2[N+](=O)[O-])cc1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.70
▸ TDP1 Q9NUW8 2/20 0.70
▸ MYC P01106 1/20 0.53
▸ MAX P61244 1/20 0.53
▸ CASP6 P55212 1/20 0.51
▸ ADAMTS4 O75173 1/20 0.51
▸ ERN1 O75460 1/20 0.48
▸ HCAR3 P49019 2/20 0.48
▸ TSHR P16473 2/20 0.47
▸ POLB P06746 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ SRD5A2 P31213 1/20 0.47
▸ AVPR2 P30518 1/20 0.47
▸ AVPR1A P37288 1/20 0.47
▸ MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL27502524 0.85 ALDH1A1 (0.88) ALDH1A1TDP1ADAMTS4TSHRLMNA
SCHEMBL2403547 0.85 GPR35 (0.55) ALDH1A1TDP1MYCMAXCASP6
SCHEMBL9310402 0.85 ALDH1A1 (0.62) ALDH1A1TDP1ADAMTS4POLBMAPK1
SCHEMBL28534102 0.85 ALDH1A1 (0.62) ALDH1A1TDP1CASP6ADAMTS4HCAR3
SCHEMBL2958562 0.83 ALDH1A1 (0.92) ALDH1A1TDP1ADAMTS4TSHRPOLB
SCHEMBL44392 0.83 ALDH1A1 (1.00) ALDH1A1TDP1ADAMTS4TSHRMAPK1
SCHEMBL30196067 0.83 ALDH1A1 (1.00) ALDH1A1TDP1ADAMTS4TSHRMAPK1
Benzene SCHEMBL28038982 0.83 ALDH1A1 (1.00) ALDH1A1TDP1ADAMTS4TSHRMAPK1
SCHEMBL9557826 0.83 CASP6 (0.66) TDP1CASP6ERN1HCAR3TSHR
SCHEMBL28669741 0.82 ALDH1A1 (0.64) ALDH1A1TDP1CASP6ERN1HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240389450-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE Sharp Display Technology Corporation (JP) 2024-11-21 — — US disclosed
US-20240376076-A1 INHIBITORS TARGETING UBIQUITIN SPECIFIC PROTEASE 7 (USP7) DANA-FARBER CANCER INSTITUTE, INC. 2024-11-14 — — US disclosed
EP-4373816-A1 INHIBITORS TARGETING UBIQUITIN SPECIFIC PROTEASE 7 (USP7) Dana-Farber Cancer Institute, Inc. (US) 2024-05-29 — — EP disclosed
CN-117981493-A Light-emitting element, method for manufacturing light-emitting element, display device, and method for manufacturing display device 夏普显示科技株式会社 2024-05-03 — — CN disclosed
WO-2023079616-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE シャープディスプレイテクノロジー株式会社 2023-05-11 — — WO disclosed
WO-2023003973-A1 INHIBITORS TARGETING UBIQUITIN SPECIFIC PROTEASE 7 (USP7) DANA-FARBER CANCER INSTITUTE, INC. (US) 2023-01-26 — — WO disclosed
CN-103172612-A Dibenzo iodonium salts and anticancer application thereof UNIV SUN YAT SEN CANCER CT 2013-06-26 — — CN disclosed
US-8008301-B2 (2-(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone; treatment of nervous system disorder, obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases ELI LILLY AND COMPANY (US) 2011-08-30 — — US disclosed
US-7745424-B2 Alkane diol derivatives as therapeutic agents for the treatment of bone conditions The Univeristy Court of the University of Aberdeen (GB) 2010-06-29 — — US disclosed
US-20100048580-A1 HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES BEAVERS LISA SELSAM 2010-02-25 — — US disclosed
EP-1778658-A2 MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF Siena Biotech S.p.A. (IT) 2007-05-02 — — EP disclosed
EP-1735278-A1 HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES ELI LILLY AND COMPANY (US) 2006-12-27 — — EP disclosed
EP-1441716-B1 ALKANE DIOL DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS UNIV ABERDEEN (GB) 2006-05-31 — — EP disclosed
WO-2006008133-A2 MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF SIENA BIOTECH S.P.A. (IT) 2006-01-26 — — WO disclosed
WO-2005097740-A1 HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES ELI LILLY AND COMPANY (US) 2005-10-20 — — WO disclosed
US-20040254151-A1 Alkane diol derivatives as therapeutic agents for the treatment of bone conditions UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, THE (GB) 2004-12-16 — — US disclosed
EP-1441716-A1 ALKANE DIOL DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS The University Court of The University of Aberdeen (GB) 2004-08-04 — — EP disclosed
WO-2003037321-A1 ALKANE DIOL DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2003-05-08 — — WO disclosed
US-5965763-A Biphenyl compounds HOECHST MARION ROUSSEL (FR) 1999-10-12 — — US disclosed
US-5827887-A 5-ALPHA REDUCTASE INHIBITORS ROUSSEL UCLAF (FR) 1998-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048580-A1 HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES HRH3, HRH4, HCRTR1 ALDH1A1 2304/4885TDP1 3770/4885MYC 4735/4885
US-20240376076-A1 INHIBITORS TARGETING UBIQUITIN SPECIFIC PROTEASE 7 (USP7) USP7, USP47, USP2 ALDH1A1 2692/4885TDP1 890/4885MYC 2977/4885
US-20040254151-A1 Alkane diol derivatives as therapeutic agents for the treatment of bone conditions SOST, ENPP2, MSR1 ALDH1A1 605/4885TDP1 588/4885MYC 3102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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