Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456932 | 0.86 | TRPV4 (0.48) | KIF11KCNH2SYKMAPTSMN1; SMN2 | |
| SCHEMBL934659 | 0.86 | TRPV4 (0.48) | KIF11KCNH2SYKMAPTSMN1; SMN2 | |
| SCHEMBL2340910 | 0.85 | RXRA (0.53) | MAP4K4 | |
| Hydrochloric Acid SCHEMBL4727672 | 0.83 | TRPV4 (0.46) | KIF11KCNH2SYKMAPTSMN1; SMN2 | |
| SCHEMBL2340659 | 0.83 | CA12 (0.53) | KCNH2MAP4K4PIK3CAMINK1PI4KB | |
| SCHEMBL483725 | 0.77 | HSD17B1 (0.52) | KIF11HSD17B1MAPTSMN1; SMN2MCHR1 | |
| SCHEMBL30536021 | 0.77 | KIF11 (0.52) | KIF11KCNH2MAP4K4PIK3CAMINK1 | |
| SCHEMBL322603 | 0.77 | KIF11 (0.52) | KIF11KCNH2MAP4K4PIK3CAMINK1 | |
| SCHEMBL23500079 | 0.75 | MAPT (0.53) | KIF11HSD17B1MAPTSMN1; SMN2 | |
| SCHEMBL1138580 | 0.75 | HSD17B1 (0.53) | HSD17B1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486246-B2 | Replication protein A (RPA)-DNA interaction inhibitors | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2025-12-02 | — | — | US | disclosed |
| US-20230056729-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | NATIONAL INSTITUTES OF HEALTH | 2023-02-23 | — | — | US | disclosed |
| EP-4073055-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | The Trustees of Indiana University (US) | 2022-10-19 | — | — | EP | disclosed |
| WO-2021119242-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486246-B2 | Replication protein A (RPA)-DNA interaction inhibitors | RPA1, RPA3, RPAP1 | KIF11 3339/4885KCNH2 4856/4885MAP4K4 1539/4885 |
| US-20230056729-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | RPA1, RPA3, RPAP1 | KIF11 3339/4885KCNH2 4856/4885MAP4K4 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.