Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.31 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20511939 | 0.80 | CYP1A2 (0.36) | CYP1A2CYP2D6CYP2C9CYP2C19TBXAS1 | |
| SCHEMBL19973455 | 0.77 | TBXAS1 (0.42) | CYP1A2CYP2D6CYP2C9TBXAS1AHR | |
| SCHEMBL23496600 | 0.76 | CYP11B1 (0.38) | CYP24A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23496478 | 0.76 | ENPP2 (0.36) | POLBCYP24A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL23496572 | 0.76 | CYP1A2 (0.31) | CYP24A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23496528 | 0.76 | FAAH (0.33) | CYP24A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19974013 | 0.74 | GRM2 (0.36) | CYP1A2CYP2D6CYP2C9CYP2C19TBXAS1 | |
| SCHEMBL12016623 | 0.74 | ALDH1A1 (0.39) | CYP24A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL217356 | 0.72 | ALDH1A1 (0.42) | POLBCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL26597503 | 0.72 | MEN1 (0.45) | CYP1A2CYP2D6CYP2C9CYP2C19TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566002-B2 | Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-01-31 | — | — | US | disclosed |
| US-20210179557-A1 | SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179557-A1 | SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME | DHPS, HMBS, HAVCR2 | POLB 397/4885CYP24A1 167/4885CYP1A2 438/4885 |
| US-11566002-B2 | Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same | DHPS, HMBS, HAVCR2 | POLB 397/4885CYP24A1 167/4885CYP1A2 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.