Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL504343 | 0.87 | HTR3A (0.43) | HTR3AKCNH2PIM1CHRNA7 | |
| SCHEMBL504169 | 0.82 | HTR3A (0.52) | HTR3AKCNH2CHRNA7 | |
| SCHEMBL503793 | 0.82 | CHRNA7 (0.40) | HTR3AKCNH2CHRNA7 | |
| SCHEMBL242574 | 0.82 | CHRNA7 (0.40) | HTR3AKCNH2CHRNA7 | |
| Hydrochloric Acid SCHEMBL3756715 | 0.81 | CHRNA7 (0.40) | HTR3AKCNH2CHRNA7 | |
| SCHEMBL244511 | 0.76 | MAPT (0.40) | HTR3AKCNH2CHRNA7 | |
| SCHEMBL4089385 | 0.75 | KMT2A (0.43) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL4094577 | 0.74 | KMT2A (0.43) | CHRNA7 | |
| SCHEMBL5112298 | 0.73 | HTR3A (0.45) | HTR3AKCNH2PIM1CHRNA7 | |
| SCHEMBL1782928 | 0.72 | FURIN (0.35) | HTR3AKCNH2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028967-A1 | NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-02-02 | — | — | US | claimed |
| WO-2010084121-A1 | NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-07-29 | — | — | WO | claimed |
| US-20120028967-A1 | NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-02-02 | — | — | US | disclosed |
| US-20120004214-A1 | N-OXIDES OF 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2012-01-05 | — | — | US | disclosed |
| US-20100286128-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-11-11 | — | — | US | disclosed |
| WO-2010084121-A1 | NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010084120-A1 | N-OXIDES OF 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-07-29 | — | — | WO | disclosed |
| EP-2190846-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024515-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028967-A1 | NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE | CHRNA5, CHRNA6, CHRNA3 | HTR3A 104/4885KCNH2 801/4885PIM1 3189/4885 |
| US-20100286128-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS | CHRNA2, CHRNA5, CHRNA3 | HTR3A 144/4885KCNH2 840/4885PIM1 3311/4885 |
| US-20120004214-A1 | N-OXIDES OF 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA5, CHRNA2, CHRNA3 | HTR3A 107/4885KCNH2 661/4885PIM1 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.