SCHEMBL23535481

SCHEMBL23535481

CC(=O)Nc1ccc(NC(=O)c2ccc(-c3ncc4cnc(-c5ccccc5)cn34)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 1/20 0.52
APBA1 Q02410 1/20 0.52
PTPN1 P18031 2/20 0.52
PTPN2 P17706 1/20 0.52
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
ALDH1A1 P00352 3/20 0.49
MAPT P10636 3/20 0.49
HPGD P15428 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
KDM4E B2RXH2 1/20 0.49
CYP2C19 P33261 1/20 0.49
POLB P06746 2/20 0.48
MCL1 Q07820 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ATM Q13315 1/20 0.48
HDAC1 Q13547 2/20 0.47
JAK2 O60674 1/20 0.46
OGT O15294 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23547240 0.92 PTPN1 (0.52) PTPN1PTPN2MAPTHPGDNPSR1
SCHEMBL23535577 0.83 FYN (0.48) MAPTATM
SCHEMBL28963628 0.83 ATM (0.48) ATM
SCHEMBL23535588 0.80 LDHA (0.53) ALDH1A1MAPTKDM4ETDP1ATM
SCHEMBL23535509 0.80 ALDH1A1 (0.51) PTPN1MEN1KMT2AALDH1A1MAPT
SCHEMBL23535500 0.78 MKNK1 (0.51) ALDH1A1MAPTHPGDKDM4ECYP2C19
SCHEMBL23535596 0.78 RAB9A (0.53) ALDH1A1HPGDKDM4ECYP2C19ATM
SCHEMBL23535524 0.77 FYN (0.61)
SCHEMBL23535503 0.77 FYN (0.53) ATM
SCHEMBL28963626 0.76 FYN (0.48) ATMHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768757-A CD206 modulators and uses and methods of making thereof 美利坚合众国,由健康及人类服务部部长代表 2023-03-07 CN disclosed
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation US HEALTH (US) 2023-02-23 US disclosed
EP-4077297-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) 2022-10-26 EP disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation CD209, MSR1, ARG1 CACNA1B 4257/4885APBA1 2864/4885PTPN1 1666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.