Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536030 | 0.78 | GRM2 (0.43) | OPRL1GRM2 | |
| SCHEMBL23536314 | 0.78 | GRM2 (0.43) | OPRL1GRM2 | |
| SCHEMBL23536137 | 0.77 | GRM2 (0.42) | OPRL1GRM2 | |
| SCHEMBL23536100 | 0.77 | MEN1 (0.49) | OPRL1GRM2ALDH1A1 | |
| SCHEMBL29948480 | 0.76 | GPR55 (0.38) | OPRL1CNR1ALDH1A1L3MBTL1 | |
| SCHEMBL23536358 | 0.76 | GPR55 (0.38) | OPRL1CNR1ALDH1A1L3MBTL1 | |
| SCHEMBL28867411 | 0.75 | OPRL1 (0.42) | OPRL1GRM2ALDH1A1 | |
| SCHEMBL29931877 | 0.75 | CA2 (0.43) | OPRL1GRM2 | |
| SCHEMBL23536378 | 0.74 | GRM2 (0.43) | OPRL1GRM2 | |
| SCHEMBL29932127 | 0.74 | GRM2 (0.43) | OPRL1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |