Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536235 | 0.88 | HTR6 (0.46) | HTR6KITJAK1 | |
| SCHEMBL29948528 | 0.85 | JAK1 (0.37) | ALDH1A1JAK1KMT2A | |
| SCHEMBL28867443 | 0.79 | SCN9A (0.38) | HTR6KIT | |
| SCHEMBL29931919 | 0.77 | MAPT (0.40) | ALDH1A1LMNAKDM4ESMN1; SMN2MCOLN2 | |
| SCHEMBL23536374 | 0.75 | EDNRA (0.42) | TSHRMEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL23536398 | 0.70 | SHMT2 (0.35) | ALDH1A1SMN1; SMN2HTR6KITNPC1 | |
| SCHEMBL18129575 | 0.69 | IGF1R (0.48) | — | |
| SCHEMBL29071633 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNAKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL23536418 | 0.66 | LIMK2 (0.46) | JAK1 | |
| SCHEMBL28867493 | 0.65 | NMT1 (0.38) | MCOLN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |