Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.54 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24961917 | 0.86 | NR1H3 (0.68) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL13465623 | 0.81 | TRPV4 (0.67) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL4490681 | 0.75 | PTGS2 (0.51) | HSD11B1RORC | |
| SCHEMBL4409342 | 0.75 | ALDH1A1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| Trifluoroacetic Acid SCHEMBL3610287 | 0.73 | LMNA (0.51) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL23536128 | 0.72 | LMNA (0.52) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL19185561 | 0.72 | ALDH1A1 (0.52) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL10590602 | 0.71 | LMNA (0.52) | ABCC9ABCC8KCNJ11KCNJ8TRPV4 | |
| SCHEMBL8490500 | 0.70 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL18867934 | 0.70 | LMNA (0.59) | LMNAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |