Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | LOX | P28300 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409342 | 0.83 | ALDH1A1 (0.57) | LMNAALDH1A1HTTSMN1; SMN2TRPV4 | |
| SCHEMBL13465623 | 0.82 | TRPV4 (0.67) | LMNAALDH1A1HTTSMN1; SMN2TRPV4 | |
| SCHEMBL19185561 | 0.80 | ALDH1A1 (0.52) | LMNAALDH1A1HTTSMN1; SMN2TRPV4 | |
| SCHEMBL20680957 | 0.77 | KIF11 (0.59) | MAPTCA12CA1CA2CA3 | |
| SCHEMBL14016158 | 0.77 | ENPP2 (0.48) | ALDH1A1LOX | |
| SCHEMBL7873867 | 0.77 | CA9 (0.55) | ALDH1A1SMN1; SMN2ABCC9ABCC8KCNJ11 | |
| SCHEMBL10590602 | 0.76 | LMNA (0.52) | LMNAALDH1A1HTTSMN1; SMN2TRPV4 | |
| SCHEMBL21244024 | 0.74 | LMNA (0.59) | LMNAALDH1A1HTTSMN1; SMN2LOX | |
| SCHEMBL519624 | 0.74 | LMNA (0.59) | LMNAALDH1A1HTTSMN1; SMN2LOX | |
| SCHEMBL8157323 | 0.74 | CA2 (0.59) | LMNAALDH1A1HTTSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | LMNA 3324/4885ALDH1A1 3737/4885HTT 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.