Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011123 | 0.85 | SLC9A1 (0.54) | CYP2C19HTR6ALDH1A1SLC9A1SMN1; SMN2 | |
| SCHEMBL31713546 | 0.79 | MEN1 (0.39) | CYP2C19HTR6ALDH1A1SLC9A1SMN1; SMN2 | |
| SCHEMBL23536635 | 0.76 | HSD17B10 (0.48) | LMNAHTR6ALDH1A1MAPK1HTT | |
| SCHEMBL23536550 | 0.74 | HTR6 (0.34) | LMNAHTR6ALDH1A1SLC9A1SMN1; SMN2 | |
| SCHEMBL5888672 | 0.74 | SMN1; SMN2 (0.36) | HTR6SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9117281 | 0.73 | ALDH1A1 (0.40) | CYP2C19LMNAALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL23536641 | 0.73 | HTT (0.46) | CYP2C19LMNAHTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL23536533 | 0.73 | HTR6 (0.40) | LMNAHTR6RAB9ALOXL2KDM4E | |
| SCHEMBL5140126 | 0.71 | RORC (0.39) | CYP2C19HTR6ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL23536839 | 0.71 | HSD17B10 (0.39) | CYP2C19LMNAHTR6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |