Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21262632 | 0.65 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTKMT2A | |
| SCHEMBL23536626 | 0.63 | HSD11B1 (0.46) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL31381239 | 0.61 | NEK2 (0.49) | KDM4EUSP2HTTLMNA | |
| SCHEMBL23570037 | 0.60 | OPRK1 (0.41) | KDM4EGRM4CHRM4ALDH1A1HTT | |
| SCHEMBL15849381 | 0.60 | KMT2A (0.42) | GRM4SMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL899662 | 0.60 | CHRNB2 (0.50) | CHRM4 | |
| SCHEMBL21262178 | 0.60 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL28790918 | 0.59 | LMNA (0.42) | KDM4EALDH1A1HTTLMNAMEN1 | |
| SCHEMBL12082726 | 0.59 | KDM4E (1.00) | KDM4ESLC6A7SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL25327609 | 0.58 | SPR (0.44) | GRM4USP2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |