Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536839 | 0.90 | HSD17B10 (0.39) | HSD17B10KMT2AMEN1RXFP1CRHBP | |
| SCHEMBL23536533 | 0.83 | HTR6 (0.40) | KMT2AMEN1LMNAKDM4EHTR6 | |
| SCHEMBL23536550 | 0.81 | HTR6 (0.34) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL23536666 | 0.80 | GPR119 (0.34) | HSD17B10KMT2AMEN1ALDH1A1HTR6 | |
| SCHEMBL23536671 | 0.80 | JAK2 (0.34) | HSD17B10KMT2AMEN1RXFP1CRHBP | |
| SCHEMBL23536682 | 0.80 | HTR6 (0.34) | KMT2ALMNAGAAHTR6 | |
| SCHEMBL23536612 | 0.78 | JAK2 (0.35) | LMNAKDM4EALDH1A1HTR6 | |
| SCHEMBL23536641 | 0.78 | HTT (0.46) | KMT2AMEN1LMNATSHRGAA | |
| SCHEMBL23536596 | 0.76 | SLC6A2 (0.39) | KMT2AMEN1LMNATSHRGAA | |
| SCHEMBL23536713 | 0.76 | CYP2C19 (0.41) | KMT2AMEN1LMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |