Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536635 | 0.81 | HSD17B10 (0.48) | HTR6LMNAHSD17B10ALDH1A1MEN1 | |
| SCHEMBL23536839 | 0.76 | HSD17B10 (0.39) | HTR6LMNAHSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL23536533 | 0.75 | HTR6 (0.40) | HTR6LMNALOXL2MEN1KMT2A | |
| SCHEMBL23536713 | 0.74 | CYP2C19 (0.41) | HTR6G6PDLMNALOXL2ALDH1A1 | |
| SCHEMBL23536671 | 0.73 | JAK2 (0.34) | LMNAHSD17B10LOXL2ALDH1A1MEN1 | |
| SCHEMBL23536612 | 0.73 | JAK2 (0.35) | HTR6LMNALOXL2ALDH1A1CYP2D6 | |
| SCHEMBL31713295 | 0.72 | HSD11B1 (0.39) | HTR6NSD2G6PDCCR6LMNA | |
| SCHEMBL23536609 | 0.71 | ALDH1A1 (0.40) | HTR6LMNAHSD17B10ALDH1A1MEN1 | |
| SCHEMBL23536666 | 0.71 | GPR119 (0.34) | HTR6HSD17B10CYP2C9ALDH1A1MEN1 | |
| SCHEMBL23536682 | 0.70 | HTR6 (0.34) | HTR6LMNALOXL2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |