Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536585 | 0.89 | LMNA (0.34) | LMNAALDH1A1SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL23536619 | 0.85 | TP53 (0.34) | LMNAALDH1A1SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL23536667 | 0.83 | LMNA (0.34) | LMNASMN1; SMN2SLC6A4TP53CYP3A4 | |
| SCHEMBL23536661 | 0.79 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TP53CYP3A4CYP2C9 | |
| SCHEMBL23536524 | 0.78 | SMN1; SMN2 (0.36) | LMNAALDH1A1SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL23536682 | 0.75 | HTR6 (0.34) | LMNAGBA1 | |
| SCHEMBL23536596 | 0.75 | SLC6A2 (0.39) | LMNASMN1; SMN2SLC6A4TP53CYP3A4 | |
| Formic Acid SCHEMBL23536757 | 0.75 | LMNA (0.33) | LMNASMN1; SMN2TP53CYP3A4 | |
| SCHEMBL23536839 | 0.71 | HSD17B10 (0.39) | LMNAALDH1A1SMN1; SMN2USP2CYP1A2 | |
| SCHEMBL23536635 | 0.70 | HSD17B10 (0.48) | LMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |