Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536661 | 0.84 | SMN1; SMN2 (0.46) | SLC6A3SMN1; SMN2LMNATP53GAA | |
| SCHEMBL23536619 | 0.82 | TP53 (0.34) | SMN1; SMN2LMNATP53GAAHTT | |
| SCHEMBL23536667 | 0.82 | LMNA (0.34) | SLC6A4SLC6A3SMN1; SMN2LMNATP53 | |
| SCHEMBL23536682 | 0.78 | HTR6 (0.34) | LMNAGAAHTR6CYP2D6GBA1 | |
| SCHEMBL23536524 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNATP53GAAHTT | |
| SCHEMBL23536839 | 0.77 | HSD17B10 (0.39) | SMN1; SMN2LMNAHTR6CYP3A4CYP2D6 | |
| SCHEMBL23536635 | 0.76 | HSD17B10 (0.48) | LMNAGAAHTTHTR6KMT2A | |
| SCHEMBL23536585 | 0.76 | LMNA (0.34) | SMN1; SMN2LMNATP53GAAHTT | |
| SCHEMBL23536533 | 0.75 | HTR6 (0.40) | SLC6A2SLC6A3LMNAHTR6GBA1 | |
| SCHEMBL23536666 | 0.74 | GPR119 (0.34) | SMN1; SMN2HTR6CYP3A4CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |