Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536772 | 0.89 | LMNA (0.39) | LMNASMN1; SMN2TP53ALDH1A1CYP3A4 | |
| SCHEMBL23536667 | 0.86 | LMNA (0.34) | LMNAGAASMN1; SMN2TP53HTT | |
| SCHEMBL23536619 | 0.86 | TP53 (0.34) | LMNAGAASMN1; SMN2TP53HTT | |
| SCHEMBL23536661 | 0.82 | SMN1; SMN2 (0.46) | LMNAGAASMN1; SMN2TP53HTT | |
| SCHEMBL23536524 | 0.81 | SMN1; SMN2 (0.36) | LMNAGAASMN1; SMN2TP53HTT | |
| Formic Acid SCHEMBL23536757 | 0.78 | LMNA (0.33) | LMNAGAASMN1; SMN2TP53HTT | |
| SCHEMBL23536596 | 0.76 | SLC6A2 (0.39) | LMNAGAASMN1; SMN2TP53HTT | |
| SCHEMBL23536839 | 0.74 | HSD17B10 (0.39) | LMNASMN1; SMN2ALDH1A1HTR6CYP3A4 | |
| SCHEMBL23536635 | 0.73 | HSD17B10 (0.48) | LMNAGAAHTTALDH1A1KDM4E | |
| SCHEMBL23536666 | 0.73 | GPR119 (0.34) | SMN1; SMN2ALDH1A1HTR6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |