Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.42 |
| ▸ | PFKFB1 | P16118 | 3/20 | 0.42 |
| ▸ | PFKFB2 | O60825 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 3/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170198 | 0.90 | HTR2C (0.41) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2170165 | 0.83 | HTR2C (0.46) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2353722 | 0.81 | HTR2C (0.41) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2171149 | 0.80 | HTR2C (0.41) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2356689 | 0.80 | HRH3 (0.44) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2364515 | 0.78 | HTR2C (0.39) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2170010 | 0.77 | HTR2C (0.39) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL2352725 | 0.76 | HTR2C (0.41) | HTR2CHTR2BPFKFB3PFKFB1PFKFB2 | |
| SCHEMBL29517131 | 0.72 | SCN4A (0.58) | PFKFB3PFKFB1PFKFB2MLNRSCN4A | |
| SCHEMBL26364702 | 0.72 | SCN4A (0.58) | PFKFB3PFKFB1PFKFB2MLNRSCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |