Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.37 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364515 | 0.84 | HTR2C (0.39) | HTR2CHTR2BLTA4HPOLBALDH1A1 | |
| SCHEMBL2170165 | 0.84 | HTR2C (0.46) | HTR2CHTR2BLTA4HMEN1KMT2A | |
| SCHEMBL2355313 | 0.80 | HTR2C (0.45) | HTR2CHTR2BLTA4HKMT2APFKFB2 | |
| SCHEMBL2170198 | 0.79 | HTR2C (0.41) | HTR2CHTR2BLTA4HALDH1A1PFKFB2 | |
| SCHEMBL2353722 | 0.78 | HTR2C (0.41) | HTR2CHTR2BLTA4HPOLBALDH1A1 | |
| SCHEMBL2356689 | 0.77 | HRH3 (0.44) | HTR2CHTR2BLTA4HALDH1A1KMT2A | |
| SCHEMBL2170010 | 0.75 | HTR2C (0.39) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2352725 | 0.74 | HTR2C (0.41) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL23126367 | 0.67 | TRPM8 (0.59) | TRPM8POLBALDH1A1MEN1KMT2A | |
| SCHEMBL2364602 | 0.66 | HTR2C (0.45) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045601-A2 | SYNERGISTIC EFFECTS BETWEEN SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |