Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 5/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PFKFB2 | O60825 | 2/20 | 0.39 |
| ▸ | PFKFB1 | P16118 | 2/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353722 | 0.85 | HTR2C (0.41) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2171149 | 0.84 | HTR2C (0.41) | HTR2CHTR2BLTA4HTP53PFKFB2 | |
| SCHEMBL2170198 | 0.84 | HTR2C (0.41) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2355313 | 0.83 | HTR2C (0.45) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2352725 | 0.81 | HTR2C (0.41) | HTR2CHTR2BLTA4HTSHRPFKFB2 | |
| SCHEMBL2356689 | 0.79 | HRH3 (0.44) | HTR2CHTR2BLTA4HTP53PFKFB2 | |
| SCHEMBL2364515 | 0.78 | HTR2C (0.39) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2170010 | 0.76 | HTR2C (0.39) | HTR2CHTR2BLTA4HPFKFB2PFKFB1 | |
| SCHEMBL2353030 | 0.72 | OPRM1 (0.37) | NR3C1MEN1KMT2A | |
| SCHEMBL2357176 | 0.72 | HRH3 (0.37) | HTR2BLTA4HEPHX2NR3C1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |