Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.39 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355313 | 0.80 | HTR2C (0.45) | MLNRHTR2CHTR2BPFKFB2PFKFB1 | |
| SCHEMBL2170010 | 0.79 | HTR2C (0.39) | MLNRHTR2CHTR2BPFKFB2PFKFB1 | |
| SCHEMBL2170165 | 0.79 | HTR2C (0.46) | MLNRHTR2CHTR2BPFKFB2PFKFB1 | |
| SCHEMBL2170198 | 0.79 | HTR2C (0.41) | ALDH1A1MLNRHTR2CHTR2BPFKFB2 | |
| SCHEMBL2171149 | 0.77 | HTR2C (0.41) | ALDH1A1HPGDHTR2CHTR2BPFKFB2 | |
| SCHEMBL2353722 | 0.76 | HTR2C (0.41) | ALDH1A1MLNRHTR2CHTR2BPFKFB2 | |
| SCHEMBL2364515 | 0.73 | HTR2C (0.39) | ALDH1A1HTR2CHTR2BPFKFB2PFKFB1 | |
| SCHEMBL2352725 | 0.72 | HTR2C (0.41) | HTR2CHTR2BPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL2350633 | 0.70 | OPRM1 (0.39) | HRH3ALDH1A1KMT2ALMNASCN9A | |
| SCHEMBL23373319 | 0.67 | PFKFB3 (0.53) | HRH3ALDH1A1HPGDALOX15PFKFB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |