Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27307706 | 0.89 | SLC6A2 (0.42) | SLC6A2SLC6A4C5AR1ALDH1A1KMT2A | |
| SCHEMBL22663301 | 0.80 | FFAR4 (0.43) | C5AR1 | |
| SCHEMBL20756535 | 0.80 | ADRB1 (0.53) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL21287875 | 0.79 | ALDH1A1 (0.42) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL16882199 | 0.79 | SLC6A2 (0.43) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL23554912 | 0.79 | SLC6A2 (0.38) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL27306689 | 0.78 | ALDH1A1 (0.42) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL1688137 | 0.77 | SLC6A2 (0.44) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL9785694 | 0.77 | ALDH1A1 (0.47) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 | |
| SCHEMBL11457763 | 0.77 | KMT2A (0.46) | SLC6A2SLC6A4TDP1C5AR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |