Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790520 | 0.85 | MAPK14 (0.47) | MAPK14TDP1MEN1KMT2AKDM4E | |
| SCHEMBL10832865 | 0.78 | MAPK14 (0.39) | MAPK14ADORA2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10832326 | 0.78 | PTGS2 (0.46) | MAPK14MEN1KMT2AKDM4EPTGS1 | |
| SCHEMBL11751581 | 0.72 | MAPK14 (0.49) | MAPK14MEN1KMT2AKDM4EADORA2A | |
| SCHEMBL11752620 | 0.72 | MAPK14 (0.49) | MAPK14ADORA2A | |
| SCHEMBL11752064 | 0.71 | ADORA2A (0.55) | MAPK14MEN1KMT2AKDM4EADORA2A | |
| SCHEMBL8060009 | 0.71 | PTGS1 (0.47) | MAPK14TDP1MEN1KMT2AKDM4E | |
| SCHEMBL26525871 | 0.71 | ALOX15 (0.38) | MAPK14TDP1MEN1KMT2AKDM4E | |
| SCHEMBL24212672 | 0.70 | MAPK14 (0.49) | MAPK14TDP1MEN1KMT2AADORA2A | |
| SCHEMBL926216 | 0.69 | MAPK14 (0.55) | MAPK14MEN1KMT2AKDM4EADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188814-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188814-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | IL6, IL1B, IL1A | MAPK14 1820/4885TDP1 213/4885MEN1 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.