Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.48 |
| ▸ | FPR2 | P25090 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | APOL1 | O14791 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170169 | 0.79 | SCN9A (0.54) | SCN9AFPR2DPP4RAB9A | |
| SCHEMBL2355316 | 0.79 | SCN9A (0.52) | SCN9AFPR2HTR1AHTR7DPP4 | |
| SCHEMBL2170202 | 0.74 | SCN9A (0.49) | SCN9AFPR2HTR1AHTR7DPP4 | |
| SCHEMBL3733552 | 0.74 | LMNA (0.52) | DPP4ALDH1A1TSHRRAB9ALMNA | |
| SCHEMBL2171155 | 0.74 | SCN9A (0.52) | SCN9AFPR2HTR1AHTR7DPP4 | |
| SCHEMBL11928250 | 0.73 | ALDH1A1 (0.49) | DPP4ALDH1A1TSHRHTTCYP3A4 | |
| SCHEMBL17220302 | 0.73 | GAA (0.54) | DPP4ALDH1A1TSHRRAB9ACYP3A4 | |
| SCHEMBL27828766 | 0.73 | GAA (0.54) | DPP4ALDH1A1TSHRRAB9ACYP3A4 | |
| SCHEMBL2172455 | 0.70 | SCN9A (0.60) | SCN9AFPR2HTR1AHTR7DPP4 | |
| SCHEMBL15797662 | 0.70 | LMNA (0.54) | ALDH1A1TSHRHTTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |