Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 14/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980126 | 0.87 | AGTR2 (0.52) | AGTR2DPP4 | |
| SCHEMBL2171155 | 0.86 | SCN9A (0.52) | SCN9AFPR2RAB9ADPP4 | |
| SCHEMBL2355316 | 0.82 | SCN9A (0.52) | SCN9AFPR2RAB9ADPP4 | |
| SCHEMBL2356691 | 0.79 | SCN9A (0.48) | SCN9AFPR2RAB9ADPP4 | |
| SCHEMBL2352727 | 0.77 | SCN9A (0.53) | SCN9AFPR2DPP4 | |
| SCHEMBL31376320 | 0.76 | DPP4 (0.65) | RAB9ADPP4 | |
| SCHEMBL13570514 | 0.76 | F2 (0.53) | RAB9ADPP4 | |
| SCHEMBL2170202 | 0.75 | SCN9A (0.49) | SCN9AFPR2DPP4 | |
| SCHEMBL2176481 | 0.74 | KCNH2 (0.47) | RAB9ADPP4 | |
| SCHEMBL2172455 | 0.73 | SCN9A (0.60) | SCN9AFPR2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |