Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23573491 | 1.00 | NPC1 (0.77) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL16866144 | 0.94 | NPC1 (0.86) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL2750640 | 0.88 | RAB9A (0.97) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL27264917 | 0.87 | RAB9A (1.00) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL27267057 | 0.87 | RAB9A (1.00) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL9273863 | 0.84 | NPC1 (0.70) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4983290 | 0.82 | L3MBTL1 (0.76) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL23573529 | 0.81 | OPRM1 (0.63) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL9269081 | 0.81 | RAB9A (0.65) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL25464492 | 0.80 | RAB9A (0.64) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198239-A1 | COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2021-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198239-A1 | COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR | ENTPD5, ADORA2A, ENTPD1 | NPC1 1512/4885RAB9A 2930/4885POLB 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.