Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601723 | 0.91 | PDE5A (0.36) | PDE5AHTR6MAPT | |
| SCHEMBL23601707 | 0.84 | PDE5A (0.42) | PDE5ADHODHABCG2 | |
| SCHEMBL23601734 | 0.80 | PDE5A (0.34) | PDE5A | |
| SCHEMBL23601069 | 0.78 | PDE5A (0.37) | PDE5AMAPT | |
| SCHEMBL23601722 | 0.76 | PDE5A (0.36) | PDE5A | |
| SCHEMBL23576879 | 0.76 | HTR6 (0.37) | PDE5AHTR6MKNK1PIK3CA | |
| SCHEMBL30961016 | 0.76 | HTR6 (0.37) | PDE5AHTR6MKNK1PIK3CA | |
| SCHEMBL23601804 | 0.75 | CHEK1 (0.38) | PDE5AMAPTSMN1; SMN2 | |
| SCHEMBL23601391 | 0.74 | EGFR (0.46) | — | |
| SCHEMBL23600980 | 0.73 | EGFR (0.36) | PDE5AMAPTSMN1; SMN2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |