Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601707 | 0.85 | PDE5A (0.42) | EGFRPDGFRBKDRDHODH | |
| SCHEMBL23601391 | 0.84 | EGFR (0.46) | EGFRPDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL23601069 | 0.81 | PDE5A (0.37) | EGFRPDGFRBKDR | |
| SCHEMBL23601723 | 0.81 | PDE5A (0.36) | ALDH1A1 | |
| SCHEMBL23601722 | 0.79 | PDE5A (0.36) | — | |
| SCHEMBL23601804 | 0.78 | CHEK1 (0.38) | LMNAHPGD | |
| SCHEMBL23601308 | 0.78 | CSNK2A1 (0.39) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL29909129 | 0.78 | LMNA (0.40) | LMNACYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL23577361 | 0.78 | LMNA (0.40) | LMNACYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL23601519 | 0.75 | ABCG2 (0.46) | LMNACYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |