Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422110 | 0.84 | IDO1 (0.58) | KDM1ABCHEACHEIDO1METAP2 | |
| SCHEMBL24721000 | 0.81 | HSD17B1 (0.41) | KDM1AHSD17B1HSD17B2TNF | |
| SCHEMBL23601607 | 0.81 | KDM1A (0.53) | KDM1ABCHEACHEIDO1METAP2 | |
| SCHEMBL23601916 | 0.81 | NOTUM (0.44) | KDM1AIDO1METAP2CASP3SENP7 | |
| SCHEMBL20924174 | 0.79 | KDM1A (0.68) | KDM1AIDO1METAP2 | |
| SCHEMBL23601705 | 0.79 | KDM1A (0.48) | KDM1ABCHEACHEIDO1METAP2 | |
| SCHEMBL23601162 | 0.76 | CYP11B1 (0.34) | KDM1AIDO1TNF | |
| SCHEMBL23601157 | 0.75 | AURKA (0.42) | SLC9A1 | |
| SCHEMBL16826157 | 0.75 | KDM1A (0.50) | KDM1ABCHEACHEIDO1METAP2 | |
| SCHEMBL15262893 | 0.72 | PTGS1 (0.35) | HSD17B1HSD17B2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271677-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |