Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22198919 | 0.82 | DAPK3 (0.47) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL24721358 | 0.81 | ALOX5AP (0.38) | KCNH2 | |
| SCHEMBL15262893 | 0.76 | PTGS1 (0.35) | — | |
| SCHEMBL23601152 | 0.76 | NISCH (0.40) | PIM1PDE10A | |
| SCHEMBL23601694 | 0.75 | KDM1A (0.50) | SLC9A1 | |
| SCHEMBL22186135 | 0.74 | OXTR (0.43) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL22185940 | 0.74 | IDH1 (0.44) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL23601162 | 0.74 | CYP11B1 (0.34) | PIM1PDE10AKCNH2CYP11B2 | |
| SCHEMBL19248552 | 0.72 | NPC1 (0.43) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL16088914 | 0.72 | HSD17B1 (0.42) | AURKADAPK3JAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |