Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078478 | 0.96 | CA4 (0.50) | CA4CA2SLC22A16ALDH1A1LMNA | |
| SCHEMBL5360765 | 0.92 | CA4 (0.46) | CA4CA2SLC22A16ALDH1A1LMNA | |
| SCHEMBL4283602 | 0.82 | CA4 (0.38) | CA4HSD17B10MEN1KMT2ACYP2C19 | |
| SCHEMBL11147064 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL536496 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL122314 | 0.77 | MGAM (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL305091 | 0.77 | SMN1; SMN2 (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL4388130 | 0.77 | MGAM (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL891003 | 0.77 | MGAM (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL1233485 | 0.76 | MGAM (0.42) | ALDH1A1LMNAHSD17B10ALOX15MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106463-A1 | RUBBER COMPOSITION, RUBBER MATERIAL, USE OF SAME, AND ADDITIVE | OTSUKA CHEMICAL CO., LTD. (JP) | 2022-04-07 | — | — | US | disclosed |
| EP-3845591-A1 | RUBBER COMPOSITION, RUBBER MATERIAL, USE OF SAME AND ADDITIVE | Otsuka Chemical Co., Ltd. (JP) | 2021-07-07 | — | — | EP | disclosed |