Sugi Predict

Sugi Predict / Compounds / SCHEMBL2362708

SCHEMBL2362708

SCHEMBL2362708

Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ POLB P06746 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ PKM P14618 3/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ GRN P28799 1/20 0.34
▸ SORT1 Q99523 1/20 0.34
▸ GLA P06280 1/20 0.32
▸ CYP1A2 P05177 3/20 0.32
▸ CYP2C19 P33261 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ MEN1 O00255 3/20 0.31
▸ KMT2A Q03164 3/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ CYP2D6 P10635 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2363178 0.87 PKM (0.40) L3MBTL1POLBMAPTTDP1PKM
SCHEMBL2362318 0.86 PKM (0.33) L3MBTL1POLBPKMNPC1KDM4E
SCHEMBL15076051 0.86 PKM (0.36) L3MBTL1MAPTPKMNPC1KDM4E
SCHEMBL8515200 0.85 SMN1; SMN2 (0.33) L3MBTL1POLBPKMNPC1KDM4E
SCHEMBL11899399 0.84 PKM (0.43) L3MBTL1POLBMAPTTDP1PKM
SCHEMBL13365029 0.84 POLB (0.38) L3MBTL1POLBMAPTTDP1PKM
SCHEMBL13365039 0.84 PKM (0.38) L3MBTL1POLBMAPTTDP1PKM
SCHEMBL18413181 0.82 PTPN1 (0.33) MAPTPKMNPC1
SCHEMBL18835450 0.82 PKM (0.44) L3MBTL1PKMNPC1KDM4ECYP1A2
SCHEMBL2362830 0.81 POLB (0.36) L3MBTL1POLBMAPTTDP1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3083566-B1 PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES BAYER ANIMAL HEALTH GMBH (DE) 2022-12-21 — — EP disclosed
CN-105934429-B Process for preparing 5-fluoro-1H-pyrazoles 拜耳动物保健有限责任公司 2022-03-04 — — CN disclosed
EP-3083565-B1 PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES BAYER ANIMAL HEALTH GMBH (DE) 2020-12-23 — — EP disclosed
EP-3183237-B1 PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE BAYER ANIMAL HEALTH GMBH (DE) 2019-07-24 — — EP disclosed
EP-3148984-B1 PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE BAYER ANIMAL HEALTH GMBH (DE) 2019-07-24 — — EP disclosed
WO-2018162312-A1 SPIROCYCLIC DERIVATIVES BASF SE (DE) 2018-09-13 — — WO disclosed
US-10059673-B2 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-08-28 — — US disclosed
US-9957256-B2 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-05-01 — — US disclosed
US-9845312-B2 Process for the preparation of 5-fluoro-1H-pyrazoles BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-12-19 — — US disclosed
EP-2794573-B1 NOVEL INSECTICIDAL AROMATIC AMIDES BAYER IP GMBH (DE) 2017-08-30 — — EP disclosed
EP-2794573-A1 NOVEL INSECTICIDAL AROMATIC AMIDES Bayer Intellectual Property GmbH (DE) 2014-10-29 — — EP disclosed
US-20140088153-A1 N-(3-CARBAMOYLPHENLY)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-03-27 — — US disclosed
EP-2686303-A1 N-(3-CARBAMOYLPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS Bayer Intellectual Property GmbH (DE) 2014-01-22 — — EP disclosed
WO-2013092522-A1 NOVEL INSECTICIDAL AROMATIC AMIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-27 — — WO disclosed
WO-2012126766-A1 N-(3-CARBAMOYLPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS BAYER CROPSCIENCE AG (DE) 2012-09-27 — — WO disclosed
US-20110301181-A1 halogen-substituted compounds BAYER CROPSCIENCE AG (DE) 2011-12-08 — — US disclosed
EP-2352723-A2 HALOGEN-SUBSTITUTED COMPOUNDS USED AS PESTICIDES Bayer CropScience AG (DE) 2011-08-10 — — EP disclosed
WO-2010133312-A1 HALOGEN-SUBSTITUTED COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-11-25 — — WO disclosed
WO-2010051926-A2 NEW HALOGEN-SUBSTITUTED BONDS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-05-14 — — WO disclosed
EP-2184273-A1 Halogen substituted compounds as pesticides Bayer CropScience AG (DE) 2010-05-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10059673-B2 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene CYP2F1, CYP4F2, CYP4F11 L3MBTL1 4759/4885POLB 1397/4885MAPT 3003/4885
US-20110301181-A1 halogen-substituted compounds L3MBTL4, QSOX1, L3MBTL3 L3MBTL1 4/4885POLB 1708/4885MAPT 4184/4885
US-20140088153-A1 N-(3-CARBAMOYLPHENLY)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS CBR3, CYCS, CAT L3MBTL1 91/4885POLB 3807/4885MAPT 4175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.