Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.32 |
| ▸ | MICA | Q29983 | 1/20 | 0.32 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16770635 | 1.00 | RAPGEF4 (0.37) | RAPGEF4PDE2ATACR1SLC13A3S1PR1 | |
| SCHEMBL9886102 | 0.87 | TACR1 (0.41) | PDE2ATACR1S1PR1AKR1C3AKR1C2 | |
| SCHEMBL22222396 | 0.87 | TACR1 (0.41) | PDE2ATACR1S1PR1AKR1C3AKR1C2 | |
| SCHEMBL23717170 | 0.87 | TACR1 (0.41) | PDE2ATACR1S1PR1AKR1C3AKR1C2 | |
| SCHEMBL13466014 | 0.84 | RORC (0.35) | — | |
| SCHEMBL18713699 | 0.84 | RAPGEF4 (0.41) | RAPGEF4PDE2ASLC13A3AKR1B10AKR1C4 | |
| SCHEMBL9967739 | 0.81 | RAPGEF4 (0.41) | RAPGEF4PDE2ATACR1SLC13A3S1PR1 | |
| SCHEMBL10289777 | 0.80 | TSHR (0.40) | GRNSORT1 | |
| SCHEMBL9178609 | 0.80 | ALDH1A1 (0.39) | — | |
| SCHEMBL7644300 | 0.80 | TSHR (0.40) | GRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145369-A1 | COMPOUNDS FOR TREATMENT OF HAIR LOSS | PELAGE PHARMACEUTICALS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-22 | — | — | US | disclosed |
| US-20210205305-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2021-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210205305-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | RAPGEF4 2209/4885PDE2A 3073/4885TACR1 520/4885 |
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | RAPGEF4 323/4885PDE2A 4199/4885TACR1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.